Methacholine causes reflex bronchoconstriction
نویسندگان
چکیده
منابع مشابه
Methacholine causes reflex bronchoconstriction.
To determine whether methacholine causes vagally mediated reflex constriction of airway smooth muscle, we administered methacholine to sheep either via the bronchial artery or as an aerosol via tracheostomy into the lower airways. We then measured the contraction of an isolated, in situ segment of trachealis smooth muscle and determined the effect of vagotomy on the trachealis response. Adminis...
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BACKGROUND Asthma can be difficult to diagnose, but bronchial provocation with methacholine, exercise or mannitol is helpful when used to identify bronchial hyperresponsiveness (BHR), a key feature of the disease. The utility of these tests in subjects with signs and symptoms of asthma but without a clear diagnosis has not been investigated. We investigated the sensitivity and specificity of ma...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 1999
ISSN: 8750-7587,1522-1601
DOI: 10.1152/jappl.1999.86.1.294